Healthy gut bacteria Coprococcus eutactus reduces depression-like symptoms caused by stress in adolescent mice, possibly through changes in gut microbes and brain chemicals

Genus Coprococcus significantly distinguished between healthy and unmedicated depressive adolescents.

• Transplantation of Coprococcus eutactus improved depression-like behaviors and reduced neuroinflammation in mice.
• Levels of neurotoxic neurotransmitters, such as 3-hydroxykynurenine and 3-hydroxyanthranilic acid, decreased in mouse brains following treatment with C.e.
• Treatment with C.e. altered the tryptophan metabolic pathway to favor serotonin signaling in the brain.
• In CRS mice, C.e. treatment enhanced recovery of goblet cells and mucus secretion, indicating a positive effect on gut health.
• The changes in gut microbiota included increases in beneficial genera such as Akkermansia and Roseburia after C.e. treatment.

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