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Thicker brain cortex and younger brain age in special forces veterans with blast injuries after magnesium-ibogaine treatment

Updated

Abstract

Essence

Magnesium-ibogaine treatment was associated with thicker cortex, larger subcortical volumes, and lower predicted brain age after blast TBI.

Evidence

This observational longitudinal MRI study followed 30 Special Operations Forces veterans with prior blast-induced TBI at baseline, post-treatment, and 1 month.

Caveat

Without a control group and with T1 scans sensitive to nonstructural change, the MRI shifts cannot prove neuroplastic remodeling.

Simplified

Full Text

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Funding

Competing interests

Dr. Williams is a named inventor on Stanford-owned intellectual property relating to magnesium-ibogaine. He has served on scientific advisory boards for Soneira, Salma, Otsuka, NeuraWell, Magnus Medical, and Sooma as a paid advisor. He has held equity/stock options in Soneira, Salma, Magnus Medical, NeuraWell, and Sooma. Dr. Kratter is named inventor on Stanford-owned intellectual property relating to magnesium-ibogaine; he currently receives a salary from and has equity/stock options in Soneira. Dr. Coetzee and Mr. Geoly are named inventors on Stanford-owned intellectual property relating to magnesium-ibogaine. Dr. Adamson has served as a brain injury advisor for Soneira. All other investigators declare no competing interests. To mitigate any potential bias of the aforementioned competing interests, Dr. Williams recused himself from any analytic roles or article revision. Dr. Saggar and Dr. Rolle, who are both unconflicted senior investigators, were assigned the role of supervision of data analyses and article revision.
PubMed

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