Coupling helps maintain strong daily redox rhythms in mammals despite variability and noise

Coupling between noisy oscillators can establish robust synchronized rhythms in circadian clocks.

• Circadian rhythms in mammalian cells may be generated through both transcription-translation feedback loops and redox reactions.
• Noise and heterogeneity can lead to fast desynchronization of redox oscillators.
• Synchronized rhythms can emerge from coupling between redox oscillators, with amplitude expansions and period tuning due to twist.
• Integrating redox oscillators with a transcription-translation feedback loop may enhance synchronization and amplitude under specific interaction strengths.
• These findings suggest that noise and variability play significant roles in maintaining the functionality of circadian clocks.

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