We can’t show the full text here under this license. Use the link below to read it at the source.
Development of a covalent inhibitor of gut bacterial bile salt hydrolases
Creating a lasting blocker for gut bacteria enzymes that process bile salts
AI simplified
Abstract
A covalent pan-inhibitor of gut bacterial BSHs was developed that can significantly reduce BSH activity in vivo.
- Bile salt hydrolase enzymes are crucial for the conversion of bile acids in the gut.
- The identified lead compound modifies BSH at a specific site, effectively inhibiting its activity.
- In conventional mouse feces, this inhibitor completely abolished BSH activity.
- Mice treated with the inhibitor showed reduced BSH activity and lower levels of deconjugated bile acids in their feces.
- These findings suggest that modulation of bile acid composition could be achieved using this covalent inhibitor.
AI simplified