Current atherosclerosis reportsOct 15, 2026

Single-dose gene-editing therapies targeting PCSK9 in living organisms

CRISPR Gene Editing Weekly Brief ↗PubMed ↗DOI ↗OA ↗

Updated Oct 16, 2026

Abstract

Gene editing may reduce atherosclerotic cardiovascular disease (ASCVD) by targeting PCSK9.

PCSK9 is a protein associated with cholesterol regulation and cardiovascular health.
Current gene editing technologies focus on modifying PCSK9 to potentially lower cholesterol levels.
Ongoing trials are investigating the safety and efficacy of these genetic interventions.
The findings may inform future strategies for managing ASCVD through genetic approaches.

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