World journal of gastrointestinal pathophysiologySep 30, 2025

Using CRISPR gene editing in stomach cancer: how it works, recent progress, and treatment possibilities

CRISPR Gene Editing Weekly Brief ↗PubMed ↗DOI ↗

Updated Jan 20, 2026

Abstract

CRISPR/Cas9 technology may significantly enhance understanding and treatment of gastric cancer.

CRISPR/Cas9 is being used to identify oncogenes and tumor suppressors associated with gastric cancer.
Modeling interactions within the tumor microenvironment is facilitated by CRISPR/Cas9 applications.
Recent advances in genome editing have improved knowledge of gastric cancer development and resistance to treatments.
Therapeutic gene editing using CRISPR/Cas9 faces challenges, including off-target effects and delivery methods.
Ethical considerations are an important aspect of implementing CRISPR/Cas9 in gastric cancer therapy.

Simplified

Gastric cancer (GC) remains one of the leading causes of cancer-related mortality worldwide, necessitating innovative approaches for its diagnosis and treatment. Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9), a revolutionary gene-editing technology, has emerged as a powerful tool for unraveling the molecular mechanisms underlying GC and for advancing precision medicine strategies. This review explores the current applications of CRISPR/Cas9 in GC research, including the identification of oncogenes and tumor suppressors, modeling tumor microenvironment interactions, and developing gene-based therapies. We highlight recent breakthroughs in genome editing that have enhanced our understanding of GC pathogenesis and resistance mechanisms to conventional therapies. Additionally, we discuss the potential of CRISPR/Cas9 for therapeutic gene editing in GC, addressing challenges such as off-target effects, delivery methods, and ethical considerations. By summarizing the progress and limitations of CRISPR/Cas9 in GC, this review aims to provide a comprehensive perspective on how this transformative technology could shape future strategies for the prevention, diagnosis, and treatment of GC.

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Using CRISPR gene editing in stomach cancer: how it works, recent progress, and treatment possibilities

Abstract

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