A collection of gene-edited mice for studying flu virus functions

A library of 84 gene-modified mouse lines was developed to study host factors in influenza A virus infection.

• Seventeen host factors were identified whose removal provided resistance to influenza A virus.
• Two specific factors, Arhgef28 and Lasp1, demonstrated different protective mechanisms against the virus.
• The platform aims to enhance understanding of virus-host interactions in a living organism.
• This resource may facilitate the translation of in vitro findings into practical insights regarding viral pathogenesis.

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