Nature communications

Cryptochromes are essential for clear daily rhythms in the mouse brain's internal clock

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Circadian rhythms in the suprachiasmatic nucleus (SCN) of Cry1(-/-)/Cry2(-/-) mice damp out after several cycles.

  • Neonatal SCN of Cry double deficient mice exhibit circadian rhythms at the tissue level, but these rhythms are absent in adults.
  • Cellular circadian rhythms are present in both neonatal and adult SCN, but synchronization is lost during development.
  • In neonates, cellular circadian rhythms are synchronized, while adults show a lack of this synchrony.
  • Coculture of neonatal SCN can restore synchronized rhythms in adult Cry1(-/-)/Cry2(-/-) SCN, indicating a potential method for rhythm restoration.
  • CRY1 and CRY2 are crucial for developing intercellular networks that support coherent circadian rhythm expression in adult SCN.

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