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Cryptochromes are critical for the development of coherent circadian rhythms in the mouse suprachiasmatic nucleus
Cryptochromes are essential for clear daily rhythms in the mouse brain's internal clock
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Abstract
Circadian rhythms in the suprachiasmatic nucleus (SCN) of Cry1(-/-)/Cry2(-/-) mice damp out after several cycles.
- Neonatal SCN of Cry double deficient mice exhibit circadian rhythms at the tissue level, but these rhythms are absent in adults.
- Cellular circadian rhythms are present in both neonatal and adult SCN, but synchronization is lost during development.
- In neonates, cellular circadian rhythms are synchronized, while adults show a lack of this synchrony.
- Coculture of neonatal SCN can restore synchronized rhythms in adult Cry1(-/-)/Cry2(-/-) SCN, indicating a potential method for rhythm restoration.
- CRY1 and CRY2 are crucial for developing intercellular networks that support coherent circadian rhythm expression in adult SCN.
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