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Cryptochromes: sensory reception, transduction, and clock functions subserving circadian systems
Cryptochromes: how they sense signals, send messages, and help control daily body clocks
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Abstract
Cryptochromes (CRYs) are involved in circadian rhythms across various species.
- CRYs are blue-light-absorbing proteins that affect biological processes, including circadian rhythms.
- In Drosophila, a single gene's CRY protein is used by pacemaking neurons to convert light into circadian signals.
- Drosophila CRY may function as a photoreceptive molecule in peripheral tissues, contributing to the circadian clock.
- Mice possess two CRY-encoding genes that are expressed in multiple tissues, including the retina and brain.
- In the retina, mouse CRY may support circadian functions alongside other light-sensitive proteins.
- In the brain's suprachiasmatic nucleus, mouse CRYs are integral to the complex molecular clock system.
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