We can’t show the full text here under this license. Use the link below to read it at the source.
Identification and validation of a prognostic signature of cuproptosis-related genes for esophageal squamous cell carcinoma
A gene-based signature linked to copper-related cell death that may predict outcomes in esophageal squamous cell cancer
AI simplified
Abstract
Significant expression differences were observed in most of the 12 cuproptosis-related genes in the TCGA-ESCC dataset.
- Patients in the TCGA-ESCC cohort were divided into two subgroups based on disease characteristics, showing significant differences in survival outcomes and biological functions.
- A signature comprising 11 prognosis-related genes was identified, allowing categorization of patients into high- and low-risk subgroups based on their median risk score.
- Patients in the high-risk subgroup had significantly worse overall survival compared to those in the low-risk subgroup.
- The CRGs signature showed high accuracy in predicting prognosis and survival outcomes for ESCC patients.
- Eight of the 11 cuproptosis-related genes were identified as independent prognostic factors for survival in ESCC patients through Cox regression analyses.
- The risk model developed was relevant to the sensitivity of targeted agents and immune cell infiltration, and was associated with biological pathways linked to tumor migration and invasion.
AI simplified