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CXCL5 inhibition ameliorates acute kidney injury and prevents the progression from acute kidney injury to chronic kidney disease
Blocking CXCL5 improves sudden kidney damage and helps stop it from becoming long-term kidney disease
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Abstract
Serum and renal expression of CXCL5 were increased in animals with renal ischemia-reperfusion injury or unilateral ureteral obstruction.
- CXCL5-knockout mice showed reduced systemic oxidative stress and preserved renal function during acute and chronic phases of acute kidney injury.
- Indicators of kidney function, such as serum BUN and creatinine levels, decreased in CXCL5-knockout mice.
- CXCL5-knockout mice exhibited less tubular injury and fibrosis, along with reduced infiltration of renal macrophages.
- CXCL5 may activate a pathway that leads to increased reactive oxygen species and cellular damage through its receptor CXCR2.
- Clinical data revealed elevated levels of circulating and renal CXCL5 in chronic kidney disease patients, correlated with increased renal fibrosis and decreased kidney function.
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