Effect of Daytime Blue-enriched LED Light on the Nighttime Circadian Melatonin Inhibition of Hepatoma 7288CTC Warburg Effect and Progression

Rats exposed to blue-enriched light during the day exhibited a 7-fold increase in nighttime melatonin levels compared to those in cool white fluorescent light.

• Daytime exposure to blue-enriched light amplifies nighttime melatonin signals.
• Higher melatonin levels were sustained for up to 4 hours into the light phase.
• Tumor growth rates in hepatoma xenografts were significantly delayed in rats exposed to blue-enriched light.
• Metabolic and signaling activities associated with tumor growth were reduced in the blue-enriched light group compared to the cool white light group.
• These findings suggest that enhanced melatonin signaling may inhibit liver cancer progression.

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