Daytime eating during simulated night work mitigates changes in cardiovascular risk factors: secondary analyses of a randomized controlled trial

Apr 8, 2025Nature communications

Eating during the day while working night shifts may reduce changes in heart health risk factors

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Abstract

Eating only during daytime is associated with significant modifications in cardiovascular risk factors under simulated night work conditions.

  • The meal timing intervention resulted in no significant changes in cardiac measures or prothrombotic factors in the Daytime Meal Intervention Group.
  • In the Nighttime Meal Control Group, there were observed decreases in percentage consecutive heartbeat intervals (>50 ms) by 25.7% and root mean square of successive heartbeat differences by 14.3%.
  • An increase in low/high cardiac frequency ratio by 5.5% and in plasminogen activator inhibitor-1 by 23.9% was recorded in the Control Group postmisalignment compared to baseline.
  • Blood pressure showed a significant reduction of 6-8% in the Intervention Group, with no significant changes in the Control Group.
  • Heart rate and cortisol levels did not show significant effects related to the meal timing intervention.

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Key numbers

25.7%
Decrease in
Change in cardiac vagal modulation in the Nighttime Meal Control Group post-simulated night work.
23.9%
Increase in
Change in prothrombotic factor in the Nighttime Meal Control Group post-simulated night work.
6-8%
Blood pressure reduction
Decrease in blood pressure in the Daytime Meal Intervention Group post-simulated night work.

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