Time-limited daytime feeding improves running endurance in mice without needing exercise beforehand

Day/sleep time-restricted feeding (DRF) enhances running endurance by 100% throughout the circadian cycle in both male and female mice.

• Meal timing may influence physical endurance and muscle activity patterns.
• Ablation of the circadian clock in the body or muscle appears to eliminate the endurance benefits of DRF.
• DRF seems to significantly synchronize the daily rhythms of mitochondrial function and metabolism compared to other feeding schedules.
• Knockdown of the perilipin-5 protein in muscle may replicate the endurance-enhancing effects of DRF by boosting energy metabolism.
• The study offers a comprehensive overview of how meal timing affects muscle circadian biology.

Simplified