Association of daytime sleepiness with nigrostriatal dopaminergic degeneration in early Parkinson's disease

Mar 14, 2007Journal of neurology

Daytime sleepiness linked to loss of dopamine in movement areas in early Parkinson's disease

AI simplified

Circadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

Mean dopamine transporter binding in 21 patients with Parkinson's disease was decreased, indicating potential dopaminergic degeneration.

Subjective daytime sleepiness in patients with Parkinson's disease may correlate with the degree of nigrostriatal dopaminergic degeneration.
ESS scores showed an inverse correlation with mean dopamine transporter binding in the striatum, suggesting that lower binding is associated with higher daytime sleepiness.
In patients at Hoehn and Yahr stage 2, significant correlations were found between ESS scores and binding in both the caudate nucleus and putamen.
No significant differences were observed in age, gender, or other sleep-related scores between patients at different Hoehn and Yahr stages.

AI simplified

INTRODUCTION: Many patients with Parkinson's disease (PD) report daytime sleepiness. Its etiology, however, is still not fully understood. The aim of this study was to examine if the amount of nigrostriatal dopaminergic degeneration is associated with subjective daytime sleepiness in patients with PD.

PATIENTS AND METHODS: We investigated 21 patients with PD clinically and by means of [(123)I] FP-CIT-SPECT (DaTSCAN(R)). Each patient filled in the Epworth sleepiness scale (ESS), the Parkinson's Disease Sleep Scale (PDSS), and the self-rating depression scale according to Zung (SDS) to assess sleepiness, sleep quality, and depressive symptoms.

RESULTS: The mean specific dopamine transporter binding in the 21 PD patients (60.8 +/- 10.4 years, nine females, median Hoehn and Yahr stage 2.0) was decreased. Nine patients were in Hoehn and Yahr stage 1 (58.7 +/- 6.6 years, four females; ESS score 7.4 +/- 4.5; PDSS score 105.1 +/- 30.9), the other 12 patients were in Hoehn and Yahr stage 2 (62.4 +/- 12.6 years, five females; ESS score 6.7 +/- 4.7, PDSS score 97.1 +/- 25.6). Age, gender, ESS, and PDSS scores were not significantly different in both groups. However, ESS scores showed an inverse correlation with mean DAT binding in the striatum (r = -0.627, p = 0.03), the caudate nucleus (r = -0.708, p = 0.01), and the putamen (r = -0.599, p = 0.04) in patients with Hoehn and Yahr stage 2. There was no correlation of the ESS score with age, disease duration, UPDRS motor score, PDSS score, or depression score.

CONCLUSION: Subjective daytime sleepiness seems to be associated with dopaminergic nigrostriatal degeneration in early PD.

Full Text

Full text is available at the source.

View full text (PDF) ↗View full text (HTML) ↗View full text ↗

Association of daytime sleepiness with nigrostriatal dopaminergic degeneration in early Parkinson's disease

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief

Abstract

Full Text

Related papers

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief