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Abstract
Immunization during the active phase enhances the generation of progenitor-like memory CD8+ T cells.
- Circadian rhythms influence CD8+ T cell differentiation and antiviral immunity.
- The timing of antigen encounter affects the fate of CD8+ T cells.
- Dendritic cell-intrinsic circadian clocks regulate the expression of the costimulatory ligand CD70.
- The regulation of CD70 expression by circadian clocks directs T cell differentiation.
- Aligning immune priming with circadian time may optimize T cell immunity.
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