DENR-MCT-1 helps restart protein production after early blocks to control tissue growth

The non-canonical initiation factors density regulated protein (DENR) and multiple copies in T-cell lymphoma-1 (MCT-1) are identified as selective regulators of eukaryotic translation re-initiation.

• mRNAs with upstream open reading frames containing strong Kozak sequences may specifically require DENR-MCT-1 for effective translation.
• This suggests a novel class of mRNAs that can be co-regulated, enriched for proteins involved in regulation, including oncogenic kinases.
• The findings indicate a previously unrecognized translational control system that could play a significant role in cell proliferation and tissue growth.

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