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The Deubiquitinase USP2 Modulates Photic Entrainment of the Circadian Clock at the Level of the Suprachiasmatic Nucleus
USP2 enzyme influences how the brain's circadian clock adjusts to light
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Abstract
Usp2 knockout (KO) mice exhibit disrupted entrainment of to light cues at dusk.
- USP2 is involved in regulating circadian rhythms, which follow a ~24-hour cycle.
- The expression of Usp2 is found throughout the suprachiasmatic nucleus (SCN) and in the retina.
- Usp2 KO mice have intact retinal structure and normal photoreception, indicating USP2's action is not in the retina.
- Knocking out Usp2 in the SCN leads to a light entrainment phenotype similar to that of full-body KO mice.
- In the SCN, Usp2 KO mice show reduced induction of the clock gene Per1 and decreased activation of the MAPK/ERK pathway in response to light.
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Key numbers
0.0302
Phase Shift Difference
Statistical significance of phase shift differences in response to light pulses.
0.0022
Light-Induced Per1 Induction
Statistical significance of Per1 induction levels post-light pulse.