Developmental emergence of sleep rhythms enables long-term memory in Drosophila

Sep 8, 2023Science advances

The Growth of Sleep Patterns Helps Long-Term Memory in Fruit Flies

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Abstract

Sleep rhythms begin to emerge in Drosophila larvae during the transition from second-instar (L2) to early third-instar (L3).

  • Circadian control of sleep is absent in L2 larvae, similar to human infants.
  • A cellular connection forms between clock neurons and arousal-promoting neurons at the L3 stage.
  • Emergence of circadian sleep in L3 is associated with the ability to form long-term memory of aversive cues.
  • Deep sleep, generated when sleep rhythms begin, is necessary for this long-term memory.
  • The development of circadian sleep may facilitate more complex cognitive processes.

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