Diet-Induced Type II Diabetes in C57BL/6J Mice

C57BL/6J mice exhibited fasting blood glucose levels greater than 240 mg/dl after a high-fat, high-simple-carbohydrate diet.

• Obesity was induced in both C57BL/6J and A/J mice through a high-fat, high-simple-carbohydrate diet.
• A/J mice experienced moderate glucose intolerance and insulin resistance, while C57BL/6J mice developed clear-cut diabetes.
• C57BL/6J mice had fasting blood insulin levels exceeding 150 microU/ml.
• C57BL/6J mice demonstrated greater glycemic responses to stress and epinephrine compared to A/J mice, with these responses worsened by obesity.
• Findings suggest a genetic predisposition in C57BL/6J mice for non-insulin-dependent (type II) diabetes.

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