Long-term intake of dietary fat and risk of ulcerative colitis and Crohn's disease

Among 170,805 women, 269 cases of Crohn's disease and 338 cases of ulcerative colitis were confirmed over 26 years.

• The incidence of Crohn's disease was 8 cases per 100,000 person-years, while ulcerative colitis had an incidence of 10 cases per 100,000 person-years.
• Cumulative intake of total fat, saturated fats, unsaturated fats, and specific polyunsaturated fatty acids was not associated with the risk of Crohn's disease or ulcerative colitis.
• Greater intake of long-chain n-3 polyunsaturated fatty acids showed a trend towards a lower risk of ulcerative colitis (HR 0.72).
• High long-term intake of trans-unsaturated fatty acids was associated with a trend towards an increased incidence of ulcerative colitis (HR 1.34).

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