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Abstract
Dietary patterns may significantly influence intestinal stem cell (ISC) behavior and epithelial regeneration.
- Caloric restriction, fasting, and structured feeding-fasting cycles could enhance epithelial regeneration through nutrient-sensing pathways and circadian regulation.
- Western-type and high-fat diets are associated with niche remodeling, inflammation, and an increased risk of tumors.
- Macronutrients influence ISC fate via carbohydrate metabolism, amino acid sensing, and fatty acid oxidation.
- Micronutrients like vitamins A, D, B, and minerals such as iron and zinc contribute to epithelial differentiation and barrier integrity.
- Phytochemicals may affect ISC function through various cellular pathways and by stabilizing the epithelial microenvironment.
- The gut microbiota plays a role in diet-ISC interactions by mediating effects through metabolites like short-chain fatty acids.
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