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Dietary saturated fatty acid type impacts obesity-induced metabolic dysfunction and plasma lipidomic signatures in mice
How different types of saturated fats in the diet affect obesity-related metabolism problems and blood fat patterns in mice
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Abstract
Inclusion of medium chain saturated fatty acids (MCSFA) in an obesogenic diet prevented hepatic lipid accumulation and lowered indices of insulin resistance.
- Mice fed MCSFA showed reduced obesity-induced outcomes compared to those on diets with long chain saturated fatty acids (LCSFA).
- Obesogenic diets decreased hepatic levels of proteins linked to fat production but increased inflammatory markers in adipose tissue.
- MCSFA intake resulted in a distinct lipid profile compared to LCSFA, preventing the rise of certain pro-inflammatory lipids.
- Consumption of these diets influenced plasma levels of phosphatidylcholine lipids associated with important fatty acids linked to heart health.
- Dietary type of saturated fatty acids may affect the metabolism of long chain polyunsaturated fatty acids.
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