Differential Entrainment of Peripheral Clocks in the Rat by Glucocorticoid and Feeding

The peripheral clocks in the kidney and lung are entrained by daily corticosterone injections, while the liver clock is influenced by restricted feeding.

• Corticosterone administration serves as a daily timing cue for the kidney and lung clocks, regardless of meal times.
• The liver clock is primarily entrained by a restricted feeding regimen, even with corticosterone injections provided at opposite times.
• Glucocorticoids are identified as a significant factor influencing the timing of peripheral clocks in specific organs.
• The study demonstrates that different organs have distinct mechanisms for entraining their circadian clocks.

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