Targeting a specific stress-related receptor reduces fat, builds muscle, and improves blood sugar control in early obesity

An acylated Urocortin 2 analogue (acyUCN2) may have potential benefits for metabolic health.

• Loss of lean mass during weight reduction is associated with negative effects on metabolic health and physical function.
• Urocortin 2 (UCN2) activates a specific receptor (CRF2) linked to positive outcomes in skeletal muscle and glucose metabolism.
• The evaluation of acyUCN2, both alone and with an acylated GLP-1 analogue (acyGLP-1), was conducted in preclinical obesity models.

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