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Dim light at night induces cardiac injury in zebrafish embryos via disrupted chloride homeostasis
Dim light at night may cause heart damage in zebrafish embryos by disrupting chloride balance
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Abstract
Chronic dim-light-at-night (dLAN) exposure induced cardiac injury in zebrafish and mice.
- Cardiac injury from dLAN was characterized by pericardial edema and impaired blood flow.
- Gene expression analysis indicated disruptions in inflammatory and oxidative stress responses.
- Significant suppression of a specific protein related to calcium and chloride channels was observed.
- Genetic manipulation replicated the core cardiac issues linked to dLAN exposure.
- Treatment with the diuretic bumetanide reversed cardiac dysfunction in both zebrafish and mice.
- A potential pathway involving chloride imbalance is associated with light pollution-related heart damage.
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