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Dim light melatonin onset (DLMO): A tool for the analysis of circadian phase in human sleep and chronobiological disorders
Using dim light melatonin onset (DLMO) to track body clock timing in sleep and daily rhythm disorders
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Abstract
The dim light melatonin onset (DLMO) is the most accurate marker for assessing the circadian pacemaker.
- DLMO can determine whether an individual is synchronized to a 24-hour light/dark cycle or in a free-running state.
- It is useful for evaluating phase delays or advances of circadian rhythms in individuals who are entrained.
- DLMO has clinical applications for diagnosing sleep and mood disorders, particularly in phase typing patients.
- Recent studies suggest DLMO may help assess chronobiological features of seasonal affective disorder (SAD).
- The DLMO marker can identify optimal timing for therapies like bright light or exogenous melatonin treatments.
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