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Dipeptidyl peptidase 4 inhibitors, sodium glucose cotransporter 2 inhibitors, and glucagon-like peptide 1 receptor agonists do not worsen diabetic macular edema
Common diabetes medicines do not make diabetic eye swelling worse
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Abstract
The hazard ratio for developing diabetic macular edema (DME) was 1.2 for DPP-4i use, indicating no significant association.
- DPP-4i use showed a hazard ratio of 1.2 (confidence interval 0.75 to 1.99; p = 0.43) for developing DME.
- GLP-1 receptor agonist use had a hazard ratio of 0.93 (confidence interval 0.54 to 1.61; p = 0.81) for DME occurrence.
- SGLT2-i use resulted in a hazard ratio of 0.82 (confidence interval 0.20 to 3.34; p = 0.78) regarding DME risk.
- Any use of one medication had a hazard ratio of 1.1 (confidence interval 0.75 to 1.59; p = 0.66) for DME development.
- The findings suggest no significant association between the use of these medications and the increased hazard of developing DME among patients with diabetic retinopathy.
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