The Discriminative Stimulus Properties of EGb 761, an Extract of Ginkgo biloba

A mean of 24 sessions was required for nine rats to establish stimulus control with a dose of 10 mg/kg of EGb 761.

• Stimulus control was defined as achieving 83% or more responses on the correct lever over five consecutive sessions.
• EGb 761-induced stimulus control is significantly reduced by the selective 5-HT1A antagonist WAY-100635.
• The effects of EGb 761 are not influenced by the 5-HT2 antagonist pirenperone.
• EGb 761's effects generalized to the selective 5-HT1A agonist 8-OH-DPAT, with this generalization blocked by WAY-100635.
• The findings suggest that the stimulus effects of EGb 761 may be linked to its interaction with the 5-HT1A receptor.

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