Disruption of normal circadian clock function in a mouse model of tauopathy

Tg4510 mice exhibit a long free-running period, indicating disrupted circadian rhythm associated with tauopathy.

• Circadian dysfunction is linked to neurodegenerative diseases, including Alzheimer's disease.
• Tauopathy in Tg4510 mice is present in the suprachiasmatic nucleus, the master circadian clock in the brain.
• Cyclic expression of the core clock protein PER2 is disrupted in the hypothalamus of Tg4510 mice.
• Disruption of cyclic expression is also observed for another core clock protein, BMAL1, in the hippocampus of Tg4510 mice.
• These findings suggest that tauopathy affects circadian clock function at both behavioral and molecular levels.

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