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Diuretics enhance effects of increased dose of candesartan on ambulatory blood pressure reduction in Japanese patients with uncontrolled hypertension treated with medium-dose angiotensin II receptor blockers
Diuretics boost blood pressure lowering by higher doses of candesartan in Japanese patients with uncontrolled high blood pressure on medium-dose blockers
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Abstract
A total of 146 hypertensive patients experienced significant reductions in blood pressure after switching to candesartan at 12 mg/day.
- Switching to a higher dose of candesartan resulted in significant decreases in both office and 24-hour blood pressure measurements (p<0.001).
- The proportion of patients achieving the target office blood pressure improved significantly (p=0.0014).
- The improvement in 24-hour blood pressure levels was also significant (p=0.0296).
- Patients on diuretics experienced a larger reduction in 24-hour systolic blood pressure compared to those not on diuretics (p=0.0206).
- A significant correlation was found between combined ARB and diuretic therapy and the change in 24-hour systolic blood pressure.
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