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Examination of Diurnal Variation and Sex Differences in Hippocampal Neurophysiology and Spatial Memory
Daily Changes and Sex Differences in Memory Area Activity and Spatial Memory
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Abstract
Performance on the task depended on both circadian time and sex, with memory enhanced at night in males but during the day in females.
- Long-term synaptic potentiation magnitude at CA3-CA1 synapses was greater at night compared to day for both sexes.
- Spontaneous synaptic inhibition frequency and amplitude were higher during the day regardless of sex.
- Females exhibited larger spontaneous synaptic excitation compared to males, independent of time-of-day.
- CA1 pyramidal neurons showed enhanced excitability at night, influenced by synaptic excitation and inhibition.
- The study highlights the impact of sex and circadian time on hippocampal neurophysiology.
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Key numbers
0.028
Males outperform females in at night
p-value from two-way ANOVA for male performance at night vs. day.
0.003
magnitude at night vs. day
p-value from three-way RM-ANOVA comparing magnitude.
0.008
Inhibitory synaptic transmission amplitude during day vs. night
p-value from GEE analysis of sIPSC amplitude.