Dl-3-n-butylphthalide promotes microglial phagocytosis and inhibits microglial inflammation via regulating AGE-RAGE pathway in APP/PS1 mice

May 5, 2024Brain research bulletin

Dl-3-n-butylphthalide may increase microglial cleanup and reduce microglial inflammation by affecting the AGE-RAGE pathway in Alzheimer’s model mice

AI simplified

Longevity & Aging on OpenScience ↗PubMed ↗DOI ↗

Abstract

Dl-3-n-butylphthalide (NBP) treatment significantly improved learning deficits in Alzheimer's transgenic mice.

NBP reduced total cerebral Aβ plaque deposition in APP/PS1 transgenic mice.
The treatment increased the presence of activated microglia around Aβ plaques.
Microglial phagocytosis of Aβ plaques was enhanced following NBP treatment.
NBP may influence the AGE-RAGE signaling pathway, which is involved in neuroinflammation.
A decrease in the secretion of advanced glycation end products and proinflammatory factors was observed in the hippocampus and cortex of NBP-treated mice.

AI simplified

Alzheimer's disease (AD) stands as the most prevalent neurodegenerative condition worldwide, and its correlation with microglial function is notably significant. Dl-3-n-butylphthalide (NBP), derived from the seeds of Apium graveolens L. (Chinese celery), has demonstrated the capacity to diminish Aβ levels in the brain tissue of Alzheimer's transgenic mice. Despite this, its connection to neuroinflammation and microglial phagocytosis, along with the specific molecular mechanism involved, remains undefined. In this study, NBP treatment exhibited a substantial improvement in learning deficits observed in AD transgenic mice (APP/PS1 transgenic mice). Furthermore, NBP treatment significantly mitigated the total cerebral Aβ plaque deposition. This effect was attributed to the heightened presence of activated microglia surrounding Aβ plaques and an increase in microglial phagocytosis of Aβ plaques. Transcriptome sequencing analysis unveiled the potential involvement of the AGE (advanced glycation end products) -RAGE (receptor for AGE) signaling pathway in NBP's impact on APP/PS1 mice. Subsequent investigation disclosed a reduction in the secretion of AGEs, RAGE, and proinflammatory factors within the hippocampus and cortex of NBP-treated APP/PS1 mice. In summary, NBP alleviates cognitive impairment by augmenting the number of activated microglia around Aβ plaques and ameliorating AGE-RAGE-mediated neuroinflammation. These findings underscore the related mechanism of the crucial neuroprotective roles of microglial phagocytosis and anti-inflammation in NBP treatment for AD, offering a potential therapeutic target for the disease.

Full Text

Full text is available at the source.

View full text (XML) ↗View full text ↗

Dl-3-n-butylphthalide promotes microglial phagocytosis and inhibits microglial inflammation via regulating AGE-RAGE pathway in APP/PS1 mice

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the longevity & aging brief

Abstract

Full Text

Related papers

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the longevity & aging brief