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Short-term and lasting psychological effects of a combined DMT and harmala alkaloid treatment in a phase 1 study
Updated
Abstract
Essence
An encapsulated DMT-harmala alkaloid combination produced intense acute psychedelic experiences in healthy volunteers that were linked to beneficial persisting psychological effects.
Evidence
This phase 1 study analyzed 17 dosing sessions in 9 healthy volunteers using MEQ-30, 5D-ASC, and SIME measures and found dose-related increases in acute experience scores with associations to later psychological effects.
Caveat
The evidence comes from a very small healthy-volunteer sample, so the persisting benefits are preliminary and not proof of therapeutic effect or safety in patients.
Simplified
Key numbers
65 to 115 mg
Total Dose Range
Calculated by participant weight and dose in mg/kg.
76
Score for High Dose
Observed in participants administered the high dose of formulation "C".
70.8
Score for High Dose
Mean score for participants who received formulation "C" at high dose.