Combined DMT and harmine reduce negative self-focused feelings during social self-evaluation in healthy volunteers

Declarations. Competing interests: HDA, JD, LC, DS, HPL and BQ declare that they have no conflict of interest related to this article. DAD and MS declare that they co-founded Reconnect Labs, an academic spin-off at the University of Zurich, focused on the development of psychedelic medicines for mental health, MJM declares that he owns shares of Reconnect Labs. Research ethics and patient consent: The study was conducted according to the World Medical Association Declaration of Helsinki. The study was approved by the Cantonal Ethics Committee of the Canton of Zurich (Basec-Nr. 2018-01385) and Swiss Federal Office of Public Health (BAG-Nr. (AB)-8/5-BetmG-2019/008014). Clinical trial registry name and URL incl. registration number: Neurodynamics of Prosocial Emotional Processing Following Serotonergic Stimulation With N,N-Dimethyltryptamine (DMT) and Harmine in Healthy Subjects. https://clinicaltrials.gov/ct2/show/NCT04716335