Methods (San Diego, Calif.)Oct 24, 2026

A method to efficiently disable genes in heart and skeletal muscle cells without using DNA

CRISPR Gene Editing Weekly Brief ↗PubMed ↗DOI ↗

Updated Oct 25, 2026

Abstract

Efficient gene knockout in cardiomyocyte-related cell models is critical for cardiovascular research.

Cardiomyocyte-related cell models show varying sensitivity to genome-editing techniques.
Challenges exist in achieving reproducible gene knockout across different cell types.
Cell-type-specific responses may affect the efficiency of gene editing workflows.

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