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DNAm age differences between infinium methylationEPICv1 vs EPICv2 in buffy coat, PBMC, and saliva samples
Differences in DNA methylation age between EPICv1 and EPICv2 arrays in blood and saliva samples
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Abstract
High correlations (ρ > 0.8) were observed between Infinium MethylationEPIC (EPICv1) and EPICv2 arrays in estimating age across samples from 16 healthy individuals.
- Eleven were used to estimate DNAm age from buffy coat, PBMC, and saliva samples.
- Systematic biases were introduced by EPICv2, particularly affecting non-PC-based clocks and varying by biological sample type.
- Saliva samples exhibited the greatest variability in DNAm age estimation between the two array versions.
- PC-based clocks had lower systematic bias compared to non-PC-based clocks, with Mean Absolute Percentage Error (MAPE) ranging from 0.118% to 21.2%.
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Key numbers
48 [43.5; 53.8] years
Median Age of Participants
Age range of 16 participants
-8.43 years
Mean Difference for YingCausAge
Largest absolute median difference across biological samples
> 0.8
Spearman Correlation for PC Clocks
Correlation level for most biological samples