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Dopamine D1 Receptor-Mediated Regulation of Per1, Per2, CLOCK, and BMAL1 Expression in the Suprachiasmatic Nucleus in Adult Male Rats
Dopamine D1 Receptors control daily clock gene activity in the brain’s time-keeping center of adult male rats
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Abstract
Dopamine D1 agonist injections significantly altered clock gene expressions and increased nighttime activity in adult male Wistar rats.
- Dopamine D1 agonist SKF38393 was administered at 20 mg/kg to evaluate its effects on clock gene expressions in the SCN.
- Injections during the daytime increased Per2 and CLOCK expressions while decreasing Per1 and Bmal1 expressions.
- At night, SKF38393 significantly increased Per2 expression and decreased Per1, CLOCK, and Bmal1 expressions.
- Control groups receiving saline showed significantly higher gene expressions overall, except for Per2 during nighttime.
- SKF injections resulted in a significant increase in running wheel activity during nighttime.
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