Differential effects of dopamine depletion on the distribution of [3H]SCH 23390 and [3H]spiperone binding sites in the goldfish retina.

Specific binding of dopamine D1 receptors in goldfish retina was greatest in the outer plexiform layer.

• D1 receptor binding was highest over the outer plexiform layer and horizontal cell bodies.
• D2 receptor binding was identified in two bands, one over the outer plexiform layer and the other over the inner plexiform layer.
• Depleting retinal dopamine with 6-hydroxydopamine did not affect D1 receptor binding patterns.
• D2 receptor binding was significantly reduced in the outer and inner plexiform layers after dopamine depletion.
• The findings support existing evidence of D1 and D2 receptors in both plexiform layers of the goldfish retina.

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