Neuron

Some upper brain neurons control daily rhythms and light responses in fruit flies

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Flies with overexpressed pacemaker genes remain behaviorally rhythmic under constant light conditions.

  • Wild-type Drosophila exhibit arrhythmic behavior under constant illumination.
  • Flies lacking the circadian photoreceptor CRY maintain rhythmicity even in constant light.
  • The LNvs, traditionally considered pacemaker neurons, do not drive rhythms under constant light.
  • PDF, a neuropeptide secreted by LNvs to synchronize rhythms in darkness, is not necessary for rhythmicity in constant light.
  • Molecular circadian rhythms are identified in a group of Dorsal Neurons, specifically the DN1s.
  • A subset of Dorsal Neurons can also act as pacemakers for circadian behavior, with their function enhanced by light.

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