Functional Analysis of Circadian Pacemaker Neurons inDrosophila melanogaster

Mar 3, 2006The Journal of neuroscience : the official journal of the Society for Neuroscience

Function of internal clock neurons in fruit flies

AI simplified

Circadian BiologyCircadian Biology on OpenScience ↗PubMed ↗DOI ↗OA ↗

Abstract

Evidence suggests that two groups of lateral neurons in Drosophila respond differently to light, leading to distinct morning and evening activity rhythms.

  • Drosophila exhibits bimodal activity rhythms with morning and evening bouts.
  • Two groups of lateral neurons are proposed to act as oscillators for these activity rhythms.
  • These neuronal groups can be desynchronized by constant light exposure.
  • A long-period activity component originates from the evening peak.
  • A short-period activity component is not solely derived from the morning peak but is more prominent from the evening peak.
  • This finding challenges the original model of mutually coupled oscillators governing circadian rhythms.

AI simplified

Full Text

Full text is available at the source.
View full text ↗

Related papers

Nov '07
Light increases signals from evening clock neurons and decreases signals from morning clock neurons in fruit flies
top 5% journal
cited by 139 papers
research support, non-u.s. gov't
Jul '09
Period gene activity in four brain cells is enough for daily rhythms in fruit flies under low light
top 20% journal
cited by 53 papers
research support, non-u.s. gov't
Oct '04
Morning and evening activity peaks depend on different brain clock neurons in fruit flies
cited by 642 papers
research support, non-u.s. gov't
Oct '04
Linked biological clocks control morning and evening movement in fruit flies
cited by 656 papers
research support, non-u.s. gov't
Jun '04
Two body clocks control movement rhythms and respond differently to light in fruit flies with the cryb mutation
cited by 92 papers
research support, non-u.s. gov't
Oct '03
A self-sustaining internal clock in the fruit fly brain that can be reset by light
top 5% journal
cited by 138 papers
comparative study
Mar '07
Some upper brain neurons control daily rhythms and light responses in fruit flies
top 1% journal
cited by 111 papers
research support, n.i.h., extramural
Feb '04
New aspects of light sensing by cryptochrome in the fruit fly’s brain clock
top 5% journal
cited by 158 papers
research support, non-u.s. gov't
Jul '09
Peptide-producing clock neurons in fruit flies: two peptides in specific groups of side brain cells
top 20% journal
cited by 202 papers
research support, non-u.s. gov't
Jul '09
The neuropeptide PDF directly influences evening brain cells to control several aspects of daily activity rhythms
top 5% journal
cited by 100 papers
research support, n.i.h., extramural

what lands in your inbox each week:

  • 📚7 fresh studies
  • 📝plain-language summaries
  • ✅direct links to original studies
  • 🏅top journal indicators
  • 📅weekly delivery
  • 🧘‍♂️always free

Recent issues from the circadian biology brief

issue #31
Artificial light at night disrupts bird sleep and metabolism across 675 studies
yesterday7 studies
issue #30
Your hair can reveal your circadian rhythm from a single sample
1 week ago7 studies
issue #29
Your body clock needs 25% more epidural painkiller at night
2 weeks ago7 studies
issue #28
Night owls have 123% higher mortality risk after age 81
3 weeks ago7 studies
issue #27
Light pollution linked to 31% higher diabetes risk in major analysis
4 weeks ago7 studies
issue #26
Wearables can detect early dementia signs with 70-95% accuracy across 200,000+ people
5 weeks ago7 studies
issue #25
Your brain's master clock has 7 distinct neuron types with specific jobs
6 weeks ago7 studies
issue #24
Sleep disruption in teens linked to altered circadian gene expression and future heart disease risk
7 weeks ago7 studies
issue #23
Morning-loaded eating suppresses ghrelin more than evening meals — and artificial light disrupts immune rhythms in wild rodents
8 weeks ago7 studies
issue #22
Evening people have 83% higher depression risk, while gut bacteria shape your body clock
9 weeks ago7 studies
explore the archive
See more issues from the circadian biology brief