Morning and evening peaks of activity rely on different clock neurons of the Drosophila brain

Restoring PER protein expression in specific neurons can restore morning and evening activity patterns in Drosophila.

• The brain's circadian clock in Drosophila controls locomotor activity through groups of neurons that express the Period (PER) protein.
• Targeted expression of PER in LN(v) neurons restores morning activity, while expression in both LN(v) and LN(d) neurons restores evening activity.
• This research identifies distinct neuronal bases for morning and evening activity patterns in Drosophila.
• LN(v) neurons alone are capable of generating 24-hour activity rhythms even in constant darkness.

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