Journal of biological rhythms

Daily changes of PDF protein in the upper brain area of fruit flies are not needed for their internal clock to work

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

In Drosophila, the neuropeptide pigment-dispersing factor (PDF) shows striking circadian oscillations in small LNv cell termini that require a functional molecular clock.

  • PDF is expressed in both small and large LNvs, indicating its potential involvement in circadian regulation.
  • Cyclical intensity of PDF staining is observed in small LNv cell termini, suggesting a role in synchronizing the circadian clock.
  • Transgenic flies expressing a neuropeptide fusion protein do not show cyclical accumulation of PDF or ANF-GFP in small LNv termini.
  • Absence of detectable PDF cycling does not affect behavioral rhythms, as flies exhibit normal anticipation in light-dark cycles and maintain rhythmicity in constant darkness.
  • The molecular clock in these flies remains functional, indicating that robust PDF cycling may not be critical for circadian clock output.

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