Pigment-Dispersing Factor (PDF) Has Different Effects on Drosophila's Circadian Clocks in the Accessory Medulla and in the Dorsal Brain

Oct 8, 2008Journal of biological rhythms

Pigment-dispersing factor affects fruit fly’s internal clocks differently in the accessory medulla and dorsal brain

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Abstract

Flies with altered PDF levels exhibit a range of circadian periods, with a maximum period of 24.6 hours observed in specific neural mutants.

  • In sine oculis(1) (so(1)) mutants, a higher density of PDF fibers was found in the accessory medulla, the fly's pacemaker center.
  • These so(1) mutants displayed a longer circadian period compared to control flies.
  • Elevating PDF levels in the dorsal brain led to the emergence of a shorter circadian period component alongside the longer period.
  • As PDF levels increased, the short period component decreased, reaching approximately 21 hours at very high PDF concentrations.
  • Period changes were linked to PDF, as specific double mutants exhibited a single free-running circadian period similar to Pdf 01 mutants.

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