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The Neuropeptide Pigment-Dispersing Factor Adjusts Period and Phase ofDrosophila's Clock
The pigment-dispersing factor peptide changes the timing and cycle of the fruit fly’s internal clock
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Abstract
PDF is crucial for regulating the cycling amplitude, period, and phase of clock neurons in Drosophila melanogaster.
- PDF is necessary for maintaining oscillations in certain groups of clock neurons.
- In other clock neurons, PDF is required for synchronizing the cycling of individual cells.
- Some neurons can cycle with high amplitude without PDF, but their intrinsic clock speed is influenced by PDF.
- PDF can both shorten and lengthen the circadian period in different clock neuron groups.
- Pdf(01) mutants show an inability to adapt their activity to long photoperiods as seen in wild-type flies.
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