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Drosophila CrebB is a Substrate of the Nonsense-Mediated mRNA Decay Pathway that Sustains Circadian Behaviors.
A molecule controlling daily rhythms in fruit flies is regulated by a system that removes faulty genetic messages
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Abstract
Depletion of key NMD factors in circadian pacemaker neurons decreased the amplitude of circadian locomotor behaviors.
- The nonsense-mediated mRNA decay (NMD) pathway is involved in regulating circadian rhythms in Drosophila.
- Manipulating the NMD pathway in specific clock neurons can alter the duration of free-running locomotor rhythms.
- Arrhythmic Clock mutants showed increased NMD activity in PDF-expressing neurons compared to wild-type.
- Hypomorphic mutations in Smg5 or Smg6 led to impaired circadian behaviors despite normal development of clock neurons.
- Changes in the levels of the cAMP response element-binding protein B (CrebB) were observed in NMD mutants.
- Overexpression of a transcriptional repressor form of CrebB could restore normal locomotor rhythms in Smg5-depleted flies.
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