Full text is available at the source.
A Circadian Output in Drosophila Mediated by Neurofibromatosis-1 and Ras/MAPK
Daily biological rhythms in fruit flies linked to neurofibromatosis-1 and Ras/MAPK signaling
AI simplified
Abstract
Mutant Drosophila with null mutations of the neurofibromatosis-1 (Nf1) gene exhibit circadian rhythm abnormalities.
- Altered oscillations and levels of a clock-controlled reporter are observed in Nf1 mutant flies.
- Increased activity of the mitogen-activated protein kinase (MAPK) pathway is associated with Nf1 mutations.
- Loss-of-function mutations in the Ras/MAPK pathway may rescue the circadian phenotype in these mutants.
- Circadian oscillation of phospho-MAPK is detected near nerve terminals containing pigment-dispersing factor (PDF).
- The findings suggest a potential connection between PDF signaling and Ras/MAPK pathways in regulating circadian behavior.
AI simplified