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PDF Receptor Signaling in Drosophila Contributes to Both Circadian and Geotactic Behaviors
PDF receptor signals in fruit flies affect daily rhythms and movement against gravity
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Abstract
The neuropeptide Pigment-Dispersing Factor (PDF) regulates circadian rhythms through a specific receptor that elevates cAMP levels.
- A Class II G protein-coupled receptor (PDFR) responds to PDF and other related peptides.
- Increased cAMP levels occur in response to PDF when PDFR is expressed in cells.
- Mutant flies lacking PDFR show greater circadian rhythm disruption and altered movement patterns.
- PDFR is found in various neurons, but only in a limited number of circadian pacemaker cells.
- These findings highlight the role of Class II peptide GPCR signaling in the neural circuits regulating circadian rhythms.
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