Full text is available at the source.
Drosophila GPCR Han Is a Receptor for the Circadian Clock Neuropeptide PDF
Drosophila receptor Han responds to the brain chemical that controls daily rhythms
AI simplified
Abstract
A mutation named han was identified that alters temperature preference and is linked to circadian behavior in Drosophila.
- The han mutation leads to reduced levels of the transcript CG13758.
- Han is specifically expressed in 13 pairs of circadian clock neurons in the adult Drosophila brain.
- Flies lacking han exhibited arrhythmic behavior in constant darkness, similar to flies lacking the pigment-dispersing factor (PDF).
- PDF was shown to bind to S2 cells expressing Han, resulting in increased production of a signaling molecule called cAMP.
- Han is proposed as a receptor for PDF, potentially regulating circadian rhythms by coordinating the activities of clock neurons.
AI simplified