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A G Protein-Coupled Receptor, groom-of-PDF, Is Required for PDF Neuron Action in Circadian Behavior
A specific receptor needed for daily rhythm control by PDF neurons
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Abstract
The neuropeptide Pigment-Dispersing Factor (PDF) is linked to circadian control in Drosophila through the identification of mutants that show phase-advanced evening activity.
- Mutants named groom-of-PDF (gop) exhibit phase-advanced evening activity and poor free-running rhythmicity, similar to pdf mutants.
- A spontaneous retrotransposon disrupts a coding segment of the G protein-coupled receptor CG13758 in gop mutants.
- Disruption of this receptor is associated with phase-advanced oscillations of the core clock protein PERIOD.
- Effects on circadian timing from PDF neuron perturbation are dependent on the gop mutation.
- PDF oscillations are still robust in gop mutants, indicating that GOP functions downstream of PDF.
- GOP shows strong expression in the dorsal brain near PDF-containing nerve terminals.
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